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There are people among us who believe in astrology and read their horoscopes every week. But if one segment of our diverse and ever-changing society always wants to know what the future holds for them, there must be others who would think differently. Others who may only look at astrology as a kind of guilty pleasure —similar to those TV shows and films we love to watch but would never share their titles with anyone.
Not even with our closest friends… Whether you belong to the former or the latter group, your secret is safe with us. What about the other zodiac signs? Cancers are imaginative and loyal and pledge to take care of others. According to your zodiac sign, Cancer people connect with others more easily and deeply than the rest of the zodiac. You might say that humans naturally show others affection, but something surrounds the Cancer. One possible explanation is being a water sign, along with Scorpio and Pisces, so caring for others is in their nature.
We could not live without water, right? Not to mention that Cancer is known for their ability to create a serene, friendly and inclusive atmosphere—at home or in the workplace. Other traits, such as creativity, intuition, trustworthiness, vigilance, courage and loyalty make them a great team player.
They would never leave anyone behind. Especially, because you and your fellow Cancers know how to truly listen to what others have to say. Nothing goes unnoticed under your watch. The only thing that turns Cancers into an annoying creature is their impulsiveness.
So, yes, despite or because of caring so much, sometimes they get carried away by their emotions. Considering all their zodiac characteristics, Cancer may choose a variety of career paths.
If your passion for people gets stronger as you grow older, you can find a job in the care sector. In aging societies like in Europe and North America , the number of care jobs will exponentially increase. Not only because you can focus on the youth or the elderly but also because you can pursue your passion for humans and animals.
Tough choice, we know. Perhaps you should try to gain some experience with them all. Does your true calling perhaps have something to do with the arts, the creative and the cultural sector, or the entertainment industry?
You may grab a computer and start creating, developing and implementing ideas. The best jobs for Cancer include attorney, care provider, doctor, nurse, teacher, social worker, chef, content editor and other creative freelancers, tech support provider, and so on…. Photo by Andrea Piacquadio from Pexels. One of the best jobs for Cancers where you can combine your ability to create a soothing environment is to become a massage therapist.
Since Cancers are great conversational partners and listeners, time would fly with you. And if you care about people, you should always make sure they eat enough nutrition.
The Cancer who would rather spend some time alone in a harmonious environment created for themselves could choose to become a chef. Maybe a private or home chef! While chopping the onions, grating the cheese and marinating the fish, you could get prepared for a chat filled with laughter and joy. Sometimes chefs host dinner parties, sometimes they just prepare the food and deliver it to the buyer. Your creativity could run wild as a chef.
Imagine how many ways you could decorate a cake, cook soup and set the table. And if something goes wrong, you would be alerted right away. As a freelancer, some of the best jobs for Cancers are marketing analyst , online business owner, content editor, computer systems analyst, or technical writer perhaps web developer. Working freelance also means that you need to adapt to different circumstances whenever you get a new project going on. If you think about it: caring is a core element of being a freelancer.
Your work would help others succeed. As a graphic designer or content writer, your creative thoughts lay the foundation of an outstanding packaging design and well-composed text. You may find a job as a freelancer with Verblio , Upwork , Freelancer. Teaching is an ancient profession. Teachers and students go online and meet each other for a session whenever it suits them.
Why sharing knowledge as a teacher is one of the best jobs for Cancers? Cancers should control their emotions but the better half of their personality characterized also by intuition will surely win and bring out the best in them. Photo by Helena Lopes from Pexels.
Do you think pet sitting is a job that fits your personality? You could start as a pet sitter and spend your time walking dogs and cats. Your ability to create relationships with others can come in handy when talking to pet parents.
Being vigilant and trustworthy are the traits that would make you the pet sitter every pet parent would love to hire. Your creativity could help you come up with all kinds of ideas of what to do with your four-legged or fewer clients. Just by taking them to different parks in your city would be a manifestation of that. You may start your pet sitter career with Rover , PetSitter. Pet Care and lots of other platforms. All the traits that could contribute to your success as a pet sitter could transform you into an amazing babysitter too—regardless of the age of the children.
Toddlers, kids slightly older and even teenagers can throw a tantrum. As a Cancer, you possess the ability to create a calm environment and can talk to anyone, so you would easily overcome a challenge like this. Communication plays a huge role in making it as a babysitter. Read also: Everything you need to know to get a babysitting summer job. They can share so much wisdom and stories with you. Many older people have no friends or family, so your presence would bring sunshine into their lives.
Unfortunately, many of them struggle with illnesses, therefore, they need someone vigilant next to them. You can explore job opportunities in the care sector with ElderCare. Find all opportunities here! Get introduced to a variety of app-based and Internet-based jobs in in your city!
She manages Appjobs blog and social media channels, coordinates outreach activities and cooperates with journalists and content creators around the gig economy. Get Inspired. By Paulina Bajorowicz. July 15, Last update: May 23, Job ideas for Cancer to succeed! Jobs for your zodiac sign. March 13, Last update: May 23, January 20, Last update: May 23, January 7, Last update: May 23,
Paget’s Disease of the Breast – PMC – Federal Government Employment
We strive to provide an enriched environment that fosters respect for all people and promotes diverse points of view, supports honest open dialogue and encourages collaboration. Our orientation site will help you prepare for your first day of employment and new hire orientation. Enter your email to register a profile and sign-up for job alerts, update your qualifications and receive information opportunities that match your interests.
See policies and procedures related to probationary and tenured faculty. Learn about employment vs. We are proud to be a part of what makes Houston great! We see our devotion to community outreach as an opportunity to touch and enrich many lives. We found that the greater number of abnormal gene variants were carried, the more extensive was Paget’s disease.
In addition, when we combined information from the new genes with SQSTM1 testing we were able to identify groups of people with a differing risk of severe disease as shown in the graph below. People with the fewest number of risk genes who tested negative for SQSTM1 had less severe disease lowest to medium groups whereas those with the greatest number of risk genes who also tested positive for SQSTM1 high to highest groups had the most severe disease.
The same was true for the number of affected bones. Although we found that the genes predicted severity it was a relief to find out that there was no difference in response of alkaline phosphatase activity or quality of life to treatment during the trial according to genetic risk category. This is importan t since it means that people who are at increased genetic risk of Paget’s can still respond well to treatment. We are carrying out further research to define how this information should be used in clinical practice.
One possibility is that we could offer the children of patients with Paget’s disease genetic tests for SQSTM1 and the other genes. If the tests were positive we could keep a close eye on these people to screen for early signs of Paget’s, for example by performing blood tests or bone scans periodically. The other possibility would be to actually give these people treatment to prevent the development of Paget’s as we are doing in the ZIPP study.
Before we do this we would ideally like to refine the genetic markers so that we can gain more accurate prediction and that is exactly what we are doing at present. For those members who were not able to attend and those that were, and maybe, were baffled by the biochemistry!
In my role at the University I spend about half of my time teaching biochemistry to undergraduate medical and science students. Whilst the teaching side is well supported, the total amount of funding that is allocated to research in this setting is very low in fact nil! It might seem counter-intuitive to do this, but bone remodelling is vital to ensure that the skeleton is healthy. The analogy I give is DIY around the house. You might re-decorate your utility room just to spruce it up a bit.
Then a few months later buy some new curtains in the living room and a new hall carpet. This might at the time seem futile and a waste of money.
The principal problem is with the osteoclasts – too many are produced and they are too active, resorbing bone too efficiently.
So more osteoblasts are produced to counteract the problem, and we end up in a situation where bone remodelling is dramatically increased and the new bone formed is of the wrong structure. Buy why does this happen? In the longer term, information of this type could be used to devise new treatments.
Your support has also helped us lever additional funding from other bodies to continue important aspects of this research. Whilst this is a very rare complication, it is a devastating illness, with a poor prognosis. Usually, this condition is not life-threatening by itself but in just under 1 per cent of patients a type of bone cancer known as osteosarcoma can develop.
Usually this condition is not life-threatening by itself but in just under 1 per cent of patients a type of bone cancer known as osteosarcoma can develop. Although the study used a small sample number, the results are a promising step forward in diagnosing the cancer. This small study however, shows that molecular testing could provide a robust diagnosis, which is especially useful in rare cancers.
This type of testing, detecting the switch of miR expression, could provide the crucial distinction, at an earlier stage of cancer development. Med Clin Barc ; Biomed Imaging Interv J. Breast-conserving therapy for Paget disease of the nipple: A prospective European Organization for Research and Treatment of Cancer study of 61 patients.
Dermatol Online J. Copy Download. There is no association with sun exposure or HPV. Work-Up MDP is diagnosed initially based on clinical presentation, physical examination, and breast imaging. Table 3 Mammographic findings in patients with biopsy-proven MPD.
Treatment There are no category 1 data that specifically address the local management of MPD according to the 3. Figure 3. Figure 4.
Figure 5. Prognosis Nearly all patients diagnosed with MPD have either underlying invasive or intraductal carcinoma [ 18 ]. Funding Statement This research received no external funding. Author Contributions Conceptualization, D. Institutional Review Board Statement Ethical review and approval were waived for this literature review. Informed Consent Statement Written informed consent has been obtained from the patients to publish this paper.
Conflicts of Interest The authors declare no conflict of interest. References 1. Dubar S. Ooi P. Korean J. Karakas C. Choridah L. Case Rep. Lopes Filho L. Tommaso L. Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases. Bulens P. Lim H. Kawase K. Kothari A. Paget disease of the nipple: A multifocal manifestation of higher-risk disease. Kumari N. Chiang B. Indian J. Zhao Z. Intraepidermal malignancy in breast skin: A tale of two tumours.
Sripathi S. Since the quality of medical service in economically disadvantaged Northwest China is lower, the local clinicians should be notified about MPD to fill the possible gaps in their knowledge, and further reduce missed diagnosis and misdiagnosis.
Also, for better preventing and controlling MPD etiologically, carrying out etiological research in Northwest China to identify the potential risk factors is necessary.
We used a large, nationally representative sample of the Chinese urban population which ensured the overall estimation of the prevalence of a rare disease like MPD. This nationally representative data also enabled us to explore age and sex patterns of the prevalence as well as regional differences in China.
This study also has several limitations. First, the basic medical insurance database lacks some detailed information, such as tumour stage, clinical characteristics, results of pathological examination and laboratory results, which limits the possibility to stratify the diagnosis in greater detail and analyze the data in more depth, similar to other previous studies based on claim data 58 , Second, rural inhabitants and certain urban populations, such as military soldiers are not included in the UEBMI and URBMI system because they have different types of medical insurance.
The exclusion of these groups could have affected the estimates. This population-based study investigated the prevalence of MPD in urban China based on the basic medical insurance database.
The prevalence of MPD showed a significant female predominance in China, and the rate in females was much lower than that in the United States. Female patients with MPD in China was much younger than those in developed western countries. In males, MPD were more prevalent at an older age after These findings add to our understanding of the epidemiologic characteristics of MPD in China, and at the same time, provide important implications for further epidemiological studies of MPD worldwide.
UEBMI is for employees no matter working or retired i. URBMI is for unemployed urban citizens i. No matter the proportion the insured people paid for the medical service, their reimbursement records will be kept in the database.
Information including the sociodemographic characteristics i. The detailed introduction of the two medical insurance schemes can be found in previous studies 62 , 63 , Consistent with our previous work 64 , 65 , we excluded the data of eight provinces due to absence or abnormality of crucial information such as diagnostic information Beijing, Shanghai, Sichuan, Ningxia, Hebei , only containing one insurance type Tianjin , reporting policy exemptions Fujian and Tibet.
Target patients were identified using the diagnostic information in the database i. We applied the natural language processing to normalize the diagnostic information with a dictionary of potential MPD defined by prestigious clinicians.
Diagnostic information of each potential target patient was then judged by two prestigious clinicians independently to identify actual patients with MPD. Any disagreements between them were solved by another senior clinician. The detailed case identification process can be seen in the Supplementary file. Since the reimbursement records of the insured population will be kept in the databases if they provide the national insurance card for the medical service even though no medical expense was reimbursed , almost all patients with MPD in data can be identified.
To calculate the national prevalence of MPD in , we adopted a two-stage approach, which was described in detail in our previous studies for calculating the prevalence of other rare diseases 64 , In the first stage, we calculate the prevalence of MPD in each province. In the second stage, the national or regional prevalence was calculated by pooling the prevalence of each province via random effects meta-analysis.
To stabilize the variance of province-level prevalence, the Freeman-Tukey double arcsine transformation was used. We also performed subgroup analyses by sex, age, and geographical area East, North, Northeast, Northwest, Southcentral, and Southwest. We used Student’s t-test for continuous variables and the chi-squared test for categorical variables.
All statistical analyses were done by Stata All methods were carried out in accordance with the Declaration of Helsinki. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Ashikari, R. Cancer 26 , — Kanitakis, J. Zhou, H. Targets Ther. Chen, S. Comparative study of breast cancer with or without concomitant Paget disease: an analysis of the SEER database.
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